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Adicet Bio Inc

Recommendation: Speculative Buy

Entry Date Symbol Recommendation Entry Price (USD) Target 1 (USD) Target 2 (USD) Holding Duration Potential Upside*
19 Dec, 24 ACET Speculative Buy USD 0.8954 USD 0.96 USD 1.05 17 days 17.3%

*Potential Upside (%) indicates the expected percentage increase from the Entry Price to the Target 2 Price.

Fundamentals

  • Previous Close 0.76
  • Market Cap77.37M
  • Volume156425
  • P/E Ratio-
  • Dividend Yield-%
  • EBITDA-121.49700M
  • Revenue TTM0.00000M
  • Revenue Per Share TTM-
  • Gross Profit TTM 24.99M
  • Diluted EPS TTM-1.7

Data Powered by EOD Historical Data (“EODHD”).

Company Overview

Adicet Bio, Inc., a clinical stage biotechnology company, discovers and develops allogeneic gamma delta T cell therapies for autoimmune diseases and cancer. The company offers gamma delta T cells engineered with chimeric antigen receptors (CARs) to facilitate durable activity in patients. Its lead product candidate is ADI-001, an allogeneic gamma delta T cell therapy expressing a CAR targeting CD20, which is in Phase I clinical trial for the treatment of autoimmune diseases and relapsed or refractory aggressive B cell non-Hodgkin's lymphoma. The company is also developing ADI-270, an armored gamma delta CAR T cell product candidate targeting renal cell carcinoma for treating other CD70+ solid tumor and hematological malignancies indications. The company was founded in 2014 and is based in Boston, Massachusetts.

Key Positives

Strong Financial Position: Adicet Bio, Inc. reported USD 202.1 million in cash, cash equivalents, and short-term investments, providing sufficient liquidity to fund operations through the second half of 2026, ensuring financial stability.

Reduced Net Loss: The company’s net loss narrowed to USD 30.5 million in Q3 2024, compared to USD 49.9 million in the same period in 2023, driven by reduced non-cash goodwill impairment expenses, reflecting improved financial performance.

Key Negatives

Net Loss: Despite narrowing, the company still reported a significant net loss of USD 30.5 million, which could impact future profitability and cash flow management.

Rising R&D Expenses: Total research and development expenses increased to USD 26.3 million, reflecting a slight rise due to laboratory and personnel costs, potentially indicating higher operational expenses in the future.

Key Investment Risks

Key investment risks for Adicet Bio include the potential for delays in clinical trial timelines, uncertain regulatory outcomes, and the financial burden of continued high research and development costs, which may impact the company's ability to achieve profitability in the near term.

Recommendation Summary

Technical Summary

Entry Price Support* Target 1 Target 2
0.8954 0.8 0.96 1.05

Data Source: REFINITIV, Analysis: StockNextt

*Support can be considered as an indicative stop-loss, and if prices move below that level on closing basis individuals may evaluate exiting the position depending on their risk appetite, previous holdings, and other factors considered. The support and resistance levels may need to be re-evaluated within 4-6 weeks’ time frame depending on the stock price movements from the date of recommendation on the stock.

Key Reasons for Speculative Buy

  • Financial and Operational Overview for Q3 2024: Adicet Bio, Inc., a clinical-stage biotechnology company specializing in allogeneic gamma delta T cell therapies, reported robust financial and operational outcomes for the third quarter ended September 30, 2024. The company’s financial position remains strong, with USD 202.1 million in cash, cash equivalents, and short-term investments, ensuring sufficient liquidity to fund operations through the second half of 2026. Total research and development (R&D) expenses stood at USD 26.3 million, reflecting a slight increase from the previous year, attributed to laboratory and personnel costs. General and administrative (G&A) expenses also rose modestly to USD 6.9 million. The company’s net loss narrowed to USD 30.5 million compared to USD 49.9 million in the same period in 2023, driven by reduced non-cash goodwill impairment expenses.
  • Expanding Clinical Pipeline for Autoimmune Diseases: Adicet made significant progress in its ADI-001 Phase 1 trial for autoimmune diseases, which now encompasses six indications, including lupus nephritis (LN) and systemic lupus erythematosus (SLE). The company activated clinical sites for LN and plans to expand enrollment to other indications in 2025. Preliminary data from the LN study is anticipated in the first half of 2025, with additional autoimmune indications expected in the second half of the year. Furthermore, the U.S. Food and Drug Administration (FDA) cleared an Investigational New Drug (IND) amendment, enabling the evaluation of ADI-001 in idiopathic inflammatory myopathy (IIM) and stiff person syndrome (SPS), reinforcing Adicet’s commitment to broadening its impact in autoimmune therapeutics.
  • Advancements in Hematologic Malignancies and Solid Tumor Therapies: The company continues to make strides in its solid tumor programs, with the ADI-270 candidate receiving FDA Fast Track Designation for treating metastatic/advanced clear cell renal cell carcinoma (ccRCC). This milestone underscores the therapeutic potential of gamma delta T cell therapies in addressing solid tumors. Additionally, Adicet plans to initiate a Phase 1 trial for ADI-270 in metastatic ccRCC by the end of 2024, with preliminary data expected in 2025. Recent presentations at prominent conferences, including the American Society of Gene & Cell Therapy (ASGCT) and the American College of Rheumatology (ACR), highlighted promising clinical data demonstrating robust tissue trafficking and therapeutic efficacy, further validating the company’s platform.
  • Corporate Updates and Strategic Appointments: Adicet strengthened its leadership by appointing Dr. Lloyd Klickstein to its Board of Directors. Dr. Klickstein brings over 20 years of expertise in rheumatology, immunology, and biopharmaceutical leadership, which will significantly enhance Adicet’s strategic direction. His extensive background in biomedical research and board-level leadership aligns with the company’s vision of advancing gamma delta T cell therapies for complex diseases.
  • Future Outlook and Strategic Initiatives: Looking ahead, Adicet is focused on advancing its clinical trials and expanding its therapeutic pipeline. The company aims to drive patient enrollment across its autoimmune and solid tumor indications while leveraging its gamma delta T cell platform to develop transformative therapies. Preliminary data from ADI-001 in lupus nephritis and ADI-270 in metastatic ccRCC are expected in the first half of 2025, marking key milestones in the company’s journey to address unmet medical needs in autoimmune diseases and oncology.

Technical Observation (on the daily chart):

The Relative Strength Index (RSI) over a 14-day period stands at a value of 32.89, near oversold zone, with expectations of a bullish divergence and upward momentum from the near important support zone of USD 0.85-USD 0.90. Additionally, the stock's current positioning is below both the 21-period SMA and 50-period SMA, which may serve as dynamic short to medium-term support levels.

As per the above-mentioned price action, recent key business and financial updates, momentum in the stock over the last month, and technical indicators analysis, a ‘Speculative Buy’ rating has been given for Adicet Bio, Inc. (NASDAQ: ACET) at the closing market price of USD 0.8954 as of December 18, 2024.

Key Financials in Pictures

Income Statement

Balance Sheet

Change in Cash

Total Operating Cash

Data Powered by EOD Historical Data (“EODHD”).

Peer Comparison

Sector: Healthcare Industry: Biotechnology

Company Change (USD) Price (USD) Trailing PE (x) Forward PE (x) Price Sales TTM (x) Price to Book Value (x) Enterprise Value to Revenue (x) Enterprise Value to EBITDA (x)
ACET
Adicet Bio Inc
0.04 4.64% 0.79 - - 9.72 0.35 2.14 -1.2112
NVO
Novo Nordisk A/S
-0.8143 1.17% 68.63 41.58 31.15 2.13 32.99 2.11 4.70
NONOF
Novo Nordisk A/S
0.0025 0.0036% 68.96 41.06 31.25 2.08 33.11 2.11 4.70
VRTX
Vertex Pharmaceuticals Inc
0.03 0.0062% 484.85 29.67 24.33 10.38 5.83 9.33 20.00
REGN
Regeneron Pharmaceuticals Inc
-7.26 1.14% 626.97 29.07 20.12 7.57 3.82 6.95 19.42

Data Powered by EOD Historical Data (“EODHD”).

Disclosures:

Related Risks: This report may be looked at from high-risk perspective and recommendations are provided are for a short duration. Recommendations provided in this report are solely based on technical parameters, and the fundamental performance of the stocks has not been considered in the decision-making process. Other factors which could impact the stock prices include market risks, regulatory risks, interest rates risks, currency risks, social and political instability risks etc.

Note 1: Past performance is not a reliable indicator of future performance.

Note 2: The reference date for all price data, currency, technical indicators, support, and resistance levels is December 18, 2024. The reference data in this report has been partly sourced from REFINITIV.

Technical Indicators Defined: -

Support: A level at which the stock prices tend to find support if they are falling, and a downtrend may take a pause backed by demand or buying interest. Support 1 refers to the nearby support level for the stock and if the price breaches the level, then Support 2 may act as the crucial support level for the stock.
Target: A level at which the stock prices tend to find resistance when they are rising, and an uptrend may take a pause due to profit booking or selling interest. Target 1 refers to the nearby resistance level for the stock and if the price surpasses the level, then Target 2 may act as the crucial resistance level for the stock.
Stop-loss: It is a level to protect further losses in case of unfavourable movement in the stock prices.

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